Outwitting Our Nerves

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

Although caused by vastly different pathogens, the world's three most serious infectious diseases, tuberculosis, malaria, and HIV-1 infection, share the common problem of drug resistance. The pace of drug development has been very slow for tuberculosis and malaria and rapid for HIV-1. But for each disease, resistance to most drugs has appeared quickly after the introduction of the drug. Learnin...

Our academy, our mission, our work!

This publication finds me at the half-way point of my tenure as president of the American Academy of Pain Medicine. It is therefore timely to review our academy’s goals and progress, reflecting upon and inspecting our work together as a committed and talented group of management team members and volunteer leaders. To share highlights of the year-to-date, I have created a “virtual interview,” po...

Outwitting EF-Tu and the ribosome: translation with d-amino acids

Key components of the translational apparatus, i.e. ribosomes, elongation factor EF-Tu and most aminoacyl-tRNA synthetases, are stereoselective and prevent incorporation of d-amino acids (d-aa) into polypeptides. The rare appearance of d-aa in natural polypeptides arises from post-translational modifications or non-ribosomal synthesis. We introduce an in vitro translation system that enables si...

Our Problems: Our Solutions

Discussion on the unique characteristics of psychiatry in a non-Western country like India, often tend to be limited to culture-bound syndrome like Koro, possession state etc. It is, no doubt, important for us to be able to recognize these problems and render effective treatment to individuals suffering from them. It is also interesting to speculate on the cultural factors which contribute to t...

Our adolescents--our future.